The loss of the mitochondrial membrane potential could open outer membrane pores which would result in the release of some related apoptotic proteins including cytochrome c into the cytosol and activate the caspase. Bai et al. This study was designed to develop green synthesized zinc oxide nanoparticles (ZnO-NPs) as potential nano-antibiotics against drug resistant microbes along with multifarious biomedical applications. Optical properties can be tuned by doping. Complete blood analysis showed no significant changes. Arakha et al. However, severely elicited oxidative stress particularly at higher doses was also observed by the altered erythrocyte antioxidant enzyme activities, increased in malondialdehyde (MDA) production, and marked reduction of serum total antioxidant capacity [100]. The main mechanism by which PEG-ZnO kills a cancer cell is by generating ROS and triggering p53-dependent apoptosis leading to cell death. fabricated ZnO NPs using hydroxyl ethyl cellulose as a stabilizing agent to alleviate diabetic complications [104]. The obtained ZnO NPs show an average size ranging from 24 to 40 nm. The Phβ-GBP-ZnO NPs were spherical in shape with a particle size of 20–50 nm and restrained the growth of S. aureus and P. vulgaris. HT1080 cells stained with acridine orange dye displayed remarkably orange and red fluorescence upon ZnO NPs treatment, which indicated the autophagic cells with acidic vesicular organelles. ZnO NPs was observed to be more effective in hindering the growth of El Tor (N16961) biotype of V. cholera, which was closely associated with ROS production. Copyright © 2018 Jinhuan Jiang et al. Nanotechnology research has gained momentum in recent years providing innovative solutions in the field of biomedicine, materials science, optics and electronics. A. Kattaia, and S. A. Kandeel, “Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes,”, S. C. Asani, R. D. Umrani, and K. M. Paknikar, “In vitro studies on the pleotropic antidiabetic effects of zinc oxide nanoparticles,”, K. Shanker, J. Naradala, G. K. Mohan, G. S. Kumar, and P. L. Pravallika, “A sub-acute oral toxicity analysis and comparative in vivo anti-diabetic activity of zinc oxide, cerium oxide, silver nanoparticles, and, R. M. El-Gharbawy, A. M. Emara, and S. E. Abu-Risha, “Zinc oxide nanoparticles and a standard antidiabetic drug restore the function and structure of beta cells in type-2 diabetes,”, L. Ferrero-Miliani, O. H. Nielsen, P. S. Andersen, and S. E. Girardin, “Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation,”, M. Boguniewicz and D. Y. Leung, “Atopic dermatitis: a disease of altered skin barrier and immune dysregulation,”, R. Jurakic Toncic and B. Marinovic, “The role of impaired epidermal barrier function in atopic dermatitis,”, C. Wiegand, U. C. Hipler, S. Boldt, J. Strehle, and U. Wollina, “Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis,”, M. Ilves, J. Palomaki, M. Vippola et al., “Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model,”. B. Moghaddam, M. Moniri, S. Azizi et al., “Eco-friendly formulated zinc oxide nanoparticles: induction of cell cycle arrest and apoptosis in the MCF-7 cancer cell line,”, J. Liu, X. Ma, S. Jin et al., “Zinc oxide nanoparticles as adjuvant to facilitate doxorubicin intracellular accumulation and visualize pH-responsive release for overcoming drug resistance,”, B. This autophagy induction was positively correlated with the dissolution of ZnO NPs in lysosomes to release zinc ions, and zinc ions released from ZnO NPs were able to damage lysosomes, leading to impaired autophagic flux and mitochondria. Although all these therapies seem to be very effective for killing cancer cells in theory, these nonselective therapy methods also introduce a lot of serious side effects [35]. A. Sheikh, K. M. Hoque, and P. Chakrabarti, “The antimicrobial activity of ZnO nanoparticles against, K. Ghule, A. V. Ghule, B. J. Chen, and Y. C. Ling, “Preparation and characterization of ZnO nanoparticles coated paper and its antibacterial activity study,”, A. Iswarya, B. Vaseeharan, M. Anjugam et al., “Multipurpose efficacy of ZnO nanoparticles coated by the crustacean immune molecule beta-1,3-glucan binding protein: toxicity on HepG2 liver cancer cells and bacterial pathogens,”, M. Shaban, F. Mohamed, and S. Abdallah, “Production and characterization of superhydrophobic and antibacterial coated fabrics utilizing ZnO nanocatalyst,”, K. Karthik, S. Dhanuskodi, C. Gobinath, and S. Sivaramakrishnan, “Microwave-assisted synthesis of CdO-ZnO nanocomposite and its antibacterial activity against human pathogens,”, X. Bellanger, P. Billard, R. Schneider, L. Balan, and C. Merlin, “Stability and toxicity of ZnO quantum dots: Interplay between nanoparticles and bacteria,”, K. Dedkova, B. Janikova, K. Matejova et al., “Preparation, characterization and antibacterial properties of ZnO/kaoline nanocomposites,”, M. Ramani, S. Ponnusamy, C. Muthamizhchelvan, J. Cullen, S. Krishnamurthy, and E. Marsili, “Morphology-directed synthesis of ZnO nanostructures and their antibacterial activity,”, S. Soren, S. Kumar, S. Mishra, P. K. Jena, S. K. Verma, and P. Parhi, “Evaluation of antibacterial and antioxidant potential of the zinc oxide nanoparticles synthesized by aqueous and polyol method,”, W. Salem, D. R. Leitner, F. G. Zingl et al., “Antibacterial activity of silver and zinc nanoparticles against, W. Wu, T. Liu, H. He et al., “Rheological and antibacterial performance of sodium alginate/zinc oxide composite coating for cellulosic paper,”, J. Lee, K. H. Choi, J. Min, H. J. Kim, J. P. Jee, and B. J. The biocompatible coating of these substances did not affect the anticancer action of ZnO NPs but further increased the targeting effects against cancer cells and improved the safety against normal cells. Their experiments clearly gave evidences of that only nanosized ZnO (nZnO) was able to reach into the deep layers of the allergic skin, but bulk-sized ZnO (bZnO) stayed in the upper layers of both damaged and allergic skin. ZnO NPs exhibit efficient blue emissions and near-UV emissions, which have green or yellow luminescence related to oxygen vacancies, therefore further extending its application into bioimaging field [12, 36, 120]. Abstract Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. The antibacterial effects of ZnO NPs in different bacterial species. constructed ZnO nanosheets for the imaging of cultured cells. Following studies focused on the abovementioned issues could further elucidate and comprehend the potential use of ZnO nanoparticles in biomedical diagnostic and therapeutic fields. ZnO NPs have been observed to show powerful cytotoxicity against MCF-7 cells, which was associated with the occurrence of apoptosis, more than cell cycle arrest. The typical researches about biological imaging of ZnO NPs are summarized in Table 5. The addition of radical scavengers such as mannitol, vitamin E, and glutathione could block the bactericidal action of ZnO NPs, potentially revealing that ROS production played a necessary function in the antibacterial properties of ZnO NPs. Copyright © 2021 Elsevier B.V. or its licensors or contributors. In addition, ZnO NPs have also been well known to promote the bioavailability of therapeutic drugs or biomolecules when functioning as drug carriers to achieve enhanced therapy efficiency. Download PDF Copy; Request Quote; Written by AZoNano Jul 10 2013. The … Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. Its microcrystals are very efficient light absorbers in the UVA and UVB region of spectra due to wide bandgap. In order to improve the solubility and bioavailability of curcumin, Dhivya et al. But up to now, the advanced anticancer mechanism study of ZnO NPs is still lacked of, especially in cellular and molecular mechanism strengthening. Targeted nanoparticles (NPs) also provide more therapeutic benefits besides specificity and specific localization like high payload, multidrug conjugation, easy tuning of release kinetics, selective localization, and bypass of multidrug resistance mechanism [70]. The ZnO NPs-induced apoptosis was mainly through both extrinsic and intrinsic apoptotic pathways, and some antiapoptotic genes of Bcl-2, AKT1, and JERK/2 were downregulated, while proapoptotic genes of p21, p53, JNK, and Bax were upregulated. The advent of nanotechnology has led the development of materials with new properties for use as antimicrobial agents. Mechanistic studies had proved that the loss of mitochondrial membrane potential-mediated HepG2 cell apoptosis was mainly due to the decrease in mitochondrial membrane potential and Bcl-2/Bax ratios as well as accompanying with the activation of caspase-9. Furthermore, coupled with ultraviolet (UV) illumination, Dox-ZnO nanocomplexes caused more cell death through photocatalytic properties and synergistically triggered caspase-dependent apoptosis. described a straightforward, inexpensive, and ecofriendly ZnO NPs using the root extract of P. tenuifolia and the anti-inflammatory activities were investigated in LPS-stimulated RAW 264.7 macrophages [30]. Excessive cellular damage may lead to cell death by the extension of autophagy and cellular self-consumption and result in cancer cell apoptosis [62, 63]. DOI: 10.1007/s11356-018-3787-z. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. To stabilize ZnO NPs in water, they encapsulated the ZnO NPs with silica to form ZnO@silica core-shell nanostructures. biosynthesized ZnO NPs using a new strain of yeast (Pichia kudriavzevii GY1) and evaluated their anticancer activity in breast cancer MCF-7 cells [45]. Image Credits: Kateryna Kon/shutterstock.com. XRD spectra of zinc oxide (a) nanotriangles, (b) spherical nanoparticles, and (c) nanorods. explored the effects of ZnO NPs on human liver cancer HepG2 cells and its possible pharmacological mechanism [42]. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface … investigated the regulatory mechanism of autophagy and the link between autophagy and ROS in ZnO NPs-treated lung epithelial cells [65]. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents. Here, we summarized the recent progress on the use of ZnO NPs in biomedicine. The destruction of formative neural stem cells could lead to degenerative brain disorders. So we can believe that eluted Zn2+ from ZnO NPs also take a key role in antibacterial action. Using nanoparticles in targeted drug delivery provides exciting opportunities for much more safety and effective cancer treatment. As shown in Figure 2, prior reports had suggested the main antibacterial toxicity mechanisms of ZnO NPs were based on their ability to induce excess ROS generation, such as superoxide anion, hydroxyl radicals, and hydrogen peroxide production [10]. ZnO NPs, as a new type of the low-cost and low-toxicity nanomaterial, have attracted tremendous interest in various biomedical fields, including anticancer, antibacterial, antioxidant, antidiabetic, and anti-inflammatory activities, as well as for drug delivery and bioimaging applications [9, 12]. In addition, it can be coated on various substrates to prevent bacteria from adhering, spreading, and breeding in medical devices. Physical and chemical methods for ZnO NPs preparations have widely developed. vera) and their antibacterial activity against pathogens,”, K. Ali, S. Dwivedi, A. Azam et al., “Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates,”, R. Yuvakkumar, J. Suresh, A. J. Nathanael, M. Sundrarajan, and S. I. Hong, “Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (, P. C. Nagajyothi, S. J. Cha, I. J. Yang, T. V. Sreekanth, K. J. Kim, and H. M. Shin, “Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using, A. C. Janaki, E. Sailatha, and S. Gunasekaran, “Synthesis, characteristics and antimicrobial activity of ZnO nanoparticles,”, R. Dobrucka and J. Dugaszewska, “Biosynthesis and antibacterial activity of ZnO nanoparticles using, D. Sharma, M. I. Sabela, S. Kanchi et al., “Biosynthesis of ZnO nanoparticles using, J. Qu, X. Yuan, X. H. Wang, and P. Shao, “Zinc accumulation and synthesis of ZnO nanoparticles using, H. Sharma, K. Kumar, C. Choudhary, P. K. Mishra, and B. Vaidya, “Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug,”, Y. Zhang, T. R. Nayak, H. Hong, and W. Cai, “Biomedical applications of zinc oxide nanomaterials,”, M. Martinez-Carmona, Y. Gun’ko, and M. Vallet-Regi, “ZnO nanostructures for drug delivery and theranostic applications,”, I. Singh R C, Singh O, Singh M P and Chandi P S 2008 Synthesis of zinc oxide nanorods and nanoparticles by chemical route and their comparative study as ethanol sensors Sensors Actuators B 135 352–7. The research into the danger of zinc oxide nanoparticles, which are present in some foods as well as many zinc oxide products used for skin care, is still in its early stages. Research Paper: Chronic Zinc Oxide Nanoparticles Exposure Produces Hepatic and Pancreatic Impairment in Female Rats * Corresponding author: Seyed Mohammad Hosseini, PhD. The FCP-ZnO nanocomplexes showed preferential bioaccumulation and cancer cell uptake in the folate receptors overexpressed breast cancer MDA-MB-231 cells. used the coprecipitation technique to get PEG 600 solution-modified ZnO nanoparticles (ZnO/PEG NPs), following the loading of doxorubicin (DOX) to form DOX-ZnO/PEG nanocomposites [52]. The theory analysis and experimental research proved that ZnO NPs with less side effect present greater selectivity among normal and cancerous cells. It was evidenced by an outstanding reduction of blood glucose and increasing insulin levels as well as improving serum zinc status in a time- and dose-dependent manner. Schematic illustration of antibacterial activity of ZnO NPs. In addition, ZnO NPs-treated SKOV3 cells resulted in an upregulation of LC3-I/II and p53 expression, which further induced autophagic cell death. An in vivo acute toxicity study in mice showed slight changes in liver functional tests, especially renal functional tests, compared to that of the control group. Based on its advanced intrinsic fluorescence, ZnO nanomaterial can also be used as a promising candidate for cell imaging and pathological studies. It also participates in insulin synthesis, storage, and secretion [102]. The results demonstrated that ZnO NPs could induce accumulation of autophagosomes and impairment of autophagic flux in A549 cells. ZnO NPs prepared by this method exhibited strong potential for biomedical applications such as its excellent anticancer and antibacterial activity. Diabetes mellitus is a serious public health problem, and the WHO has estimated that, in 2014, there were more than 400 million adults with diabetes all over the world [99]. E-mail: dr.m.hosseini2323@gmail.com Introduction inc Oxide (ZnO) nanoparticles are used for industrial … 4, Fig. Given the known more anti-inflammatory activity of ZnO NPs, Nagajyothi et al. DOX-ZnO/PEG nanocomposites not only enhanced the intracellular accumulation of DOX but also presented a concentration-dependent inhibition on cervical cancer HeLa cell proliferation. prepared the ZnO NPs under photocondition using the aqueous extracts of two mangrove plants, Heritiera fomes and Sonneratia apetala, and found that ZnO NPs had a higher potential for anti-inflammatory (79%) in comparison with silver nanoparticles (69.1%) [116]. These results demonstrated that ZnO NPs with a small size had great effects on reducing skin inflammation in AD models. Since the advent of nanoparticles and considering these biological activities of zinc ions, the anti-inflammatory effects of ZnO NPs have also attracted much attention. Although previous research has concluded that nanoparticles do not penetrate healthy skin, it remains contentious whether this conclusion holds under normal conditions of sunscreen use. Typical researches about biological imaging of ZnO NPs. The contribution of zinc oxide (ZnO) nanoparticles currently used in … Reddy prepared ZnO NPs with sizes of ∼13 nm and examined their antibacterial (E. coli and S. aureus) activities [78]. Compared with bZnO, nZnO exerted higher anti-inflammatory properties by decreasing drastically on proinflammatory cytokines (IL-10, IL-13, IFN-γ, and Th2 cytokines) in the mouse model of AD. Gram‐positive bacteria were generally more sensitive to ZnO than Gram negatives. ZnO NPs can be selected as an antibacterial material because of its superior properties, such as high specific surface area and high activity to block a wide scope of pathogenic agents. Some other Gram-negative bacteria such as Pseudomonas aeruginosa (P. aeruginosa) [24, 79], Proteus vulgaris (P. vulgaris) [80], Vibrio cholerae (V. cholerae) [81] and other Gram-positive bacteria such as Bacillus subtilis (B. subtilis) [82] and Enterococcus faecalis (E. faecalis) [83] are also investigated. The upper part is the high-resolution transmission electron microscopy (HRTEM) image of the ZnO@polymer core-shell nanoparticles and the aqueous solutions of ZnO-1 and ZnO-2 under a UV light; the middle part is the DIC picture and the fluorescent image of the human hepatoma cells labeled by ZnO-1; and the lower part is the DIC picture and the fluorescent image of the hepatoma cells labeled by ZnO-2 [. 5 clearly shows that the zinc oxide nanoparticles obtained by refluxing diethylene glycol and triethylene glycol for 2 h and 3 h in presence and in absence of sodium acetate have uniform shape and size with different morphology. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. However, excessive ROS will lead to mitochondrial damage and result in the loss of protein activity balance that finally causes cell apoptosis [60]. Jiang et al. A. Othman, C. Greenwood, A. F. Abuelela et al., “Correlative light-electron microscopy shows RGD-targeted ZnO nanoparticles dissolve in the intracellular environment of triple negative breast cancer cells and cause apoptosis with intratumor heterogeneity,”, N. Puvvada, S. Rajput, B. N. Kumar et al., “Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression,”, N. Tripathy, R. Ahmad, H. A. Ko, G. Khang, and Y. For example, Chakraborti et al. The emission color can be changed via adjusting the pH of the precipitation solutions. But Zn2+ released from ZnO NPs suspensions was not apparent to cause antibacterial effect. Zinc is well known to keep the structural integrity of insulin and has an active role in the secretion of insulin from pancreatic cells. It has been found that PEG-ZnO NPs were active against most of the breast cancer cell lines. Deng and Zhang also used the chemical precipitation method to prepare ZnO nanorods, which were applied for carrying Dox to construct a Dox-ZnO nanocomplex [44]. Impaired autophagic flux resulted in the accumulation of damaged mitochondria, which could generate excessive ROS to cause cell death. In 2015, Nazarizadeh and Asri-Rezaie carried out a study to compare the antidiabetic activity and oxidative stress of ZnO NPs and ZnSO4 in diabetic rats. ZnO NPs exposed remarkable anti-inflammatory activity by dose-dependently suppressing NO production as well as the related protein expressions of iNOS, COX-2, IL-1β, IL-6, and TNF-α. The mitochondrial electron transport chain is known to be associated with intracellular ROS generation, and anticancer agents entering into cancer cells could destroy the electron transport chain and release huge amounts of ROS [58, 59]. It is reported that ZnO NPs caused cell death which mostly relates to intracellular ROS generation, which further induces cancer cell death via apoptosis or the autophagy signaling pathway. Zinc Oxide (ZnO) Nanoparticles – Properties & Applications. The reports of ZnO NPs with anti-inflammatory activity are summarized in Table 4. Surface-modified ZnO NPs further improved their stability and promoted their selectivity against specific cancer cells. They treated drug sensitive leukemia line K562 cells with ZnO nanosheets, and the yellow-orange light emission was clearly observed around or inside the cells under UV irradiation (365 nm) at room temperature [122]. Aiming at the development of nanomedicine against cholera, Sarwar et al. For another nanocomposite, PMMA-AA/ZnO NPs with a size of 42 ± 5 nm could carry a large amount of curcumin and also had obvious antiproliferation on AGS cancer cells. The authors declare that they have no conflicts of interest. The Zinc Oxide nanoparticles are known to be one of the multifunctional inorganic nanoparticles and Zinc Oxide crystallites have been synthesized by simple and ecofriendly method. The anticancer activity of ZnO NPs in different cancers is presented in Table 1. It showed that ZnO NPs with an average size about 30 nm caused cell death by directly contacting with the phospholipid bilayer of the membrane, destroying the membrane integrity. Results showed that ZnO-RSW conjugate possessed moderately higher percentage of inhibition (20%) against porcine pancreatic α-amylase and were more effective against the crude murine pancreatic glucosidase than any of the two elements (RSW and ZnO NPs). So, as a type of safe and cheap luminescent labels, the ZnO@polymer core-shell nanoparticles can be used as fluorescent probes for cell imaging in vitro [121]. The developed ZnO-NPs with an average size of 19.57 ± 1.56 nm, synthesized using a Neem plant (Azadirachta indicia) extract, were characterized for zeta potential, crystalline structure using X-ray diffraction, surface morphology using scanning electron microscopy and FTIR analysis. established a new ZnO hollow nanocarrier (HZnO) engineered with biocompatible substrates by surface following conjugation with targeting agent folic acid (FA) and loaded with paclitaxel (PAC) to designate as the FCP-ZnO nanocomplex [48]. Scholar Research Library Nano zinc oxide is non-toxic, with wide band gap has also been identified as a promising semiconductor material for exhibiting ferromagnetism (RTFM) at room temperature when doped with most of the transition metal elements [15]. Alessio Becheri 1, Maximilian Dürr 1, Pierandrea Lo Nostro 1 & Piero Baglioni 1 Journal of Nanoparticle Research volume 10, pages 679 – 689 (2008)Cite this article. Review articles are excluded from this waiver policy. Abstract. The ZnO nanoparticles prepared via sol-gel route were highly crystalline and had smaller crystallite size (~ 24 nm) as compared to the one prepared by Solid state reaction method (~ 37 nm). Abstract In this research, zinc oxide (ZnO) nanoparticles were prepared through a chemical co-precipitation route using zinc acetate dihydrate and sodium hydroxide as the reactants. ZnO nanostructures were successfully attached onto or penetrated into the cells, which suggested that ZnO nanosheets with visible yellow-orange emission could act as a feasible label for the bioimaging. Visualization of LC3 immunofluorescence showed a remarkable fluorescence and an essential component of autophagosome after exposure of SKOV3 cells at higher concentration of ZnO NPs. However, some critical issues of ZnO NPs still need to be further explored, which include the following: (1) lack of comparative analysis of its biological advantages with other metal nanoparticles, (2) the limitations of ZnO NPs toxicity toward biological systems remain a controversial issue in recent researches, (3) lack of evidence-based randomized research specifically exploring therapeutic roles in improving anticancer, antibacterial, anti-inflammatory, and antidiabetic activities, and (4) lack of insight into corresponding animals study about its anticancer, antibacterial, anti-inflammatory, and antidiabetic activities. CuO particles showed rod shaped/ellipsoid morphology. Properties of Zinc Oxide Nanoparticles and Their Activity Against Microbes Khwaja Salahuddin Siddiqi1, Aziz ur Rahman2, Tajuddin2 and Azamal Husen3* Abstract Zinc oxide is an essential ingredient of many enzymes, sun screens, and ointments for pain and itch relief. Also, the histopathology of vital organs for the treatment group showed no structural changes in major organs. Moreover, with the ability to decrease blood glucose and increase in insulin levels, ZnO NPs have shown the promising potential in treating diabetes and attenuating its complications, which can be further evaluated. Department of Chemistry, Physical Chemistry Laboratory, S. S. J. The antibacterial potentiality of zinc oxide (ZnO) nanoparticles (NPs), compared with conventional ZnO powder, against nine bacterial strains, mostly foodborne including pathogens, was evaluated using qualitative and quantitative assays. The treatment group showed no structural changes in major organs morphology [ 85 ] b ) spherical nanoparticles and! Cause cell death cancer cells the Macau Science and Technology, https: //doi.org/10.1016/j.jddst.2020.101911 therefore, in! Be able to penetrate injured skin and injured allergic skin in the size range of nm! 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Dox but also presented a concentration-dependent inhibition on cervical cancer HeLa cell.. For use as antimicrobial agents Dox-ZnO nanocomplexes caused more cell death able to penetrate injured skin and allergic! Patil synthesized ZnO NPs are summarized in Table 5 aureus ) activities [ 78 ] 24... An effective antidiabetic agent in order for zinc delivery have been reported for nanoparticle modification coated various. Imaging and pathological studies: Department of Pathobiology, Babol Branch, Islamic Azad Univer-sity abundantly found mineral all! Preferential bioaccumulation and cancer cell uptake in the secretion of insulin from cells. Have widely developed high-res image ( 209KB ) Download: Download full-size image pancreatic and small extracts. Crustacean immune molecule β-1,3-glucan binding protein ( Phβ-GBP ) from aqueous solutions breeding in medical devices autophagy in cancer,! 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